Macromolecular crystallography with a third-generation synchrotron source
نویسندگان
چکیده
منابع مشابه
Macromolecular crystallography with a third-generation synchrotron source.
The European Synchrotron Radiation Facility (ESRF) at Grenoble, France, is a 6 GeV machine producing hard X-radiation that can be used for pure and applied research in a wide range of disciplines including physics, chemistry, structural biology, materials science, the earth sciences, engineering and medicine. The overall nature of the machine will be described, including the features that give ...
متن کاملStrategies for macromolecular synchrotron crystallography.
Introduction During the past ten years the rate of protein structure determination by X-ray crystallography has risen about tenfold [1]. The use of synchrotron radiation was instrumental for this growth and the fraction of the results obtained this way increased from 28% in 1990 to 80% in 1999 (Figure 1). There are 52 synchrotron stations worldwide used for macromolecular crystallography, and t...
متن کاملInstrumentation for synchrotron-radiation macromolecular crystallography.
X-ray diffraction is an extremely important tool for structure determination of biological macromolecules, to the extent that currently around 85% of Protein Data Bank entries result from X-ray measurements. Many of these structure determinations use synchrotron radiation for data collection. This article aims to give synchrotron users an overview of the functioning of a synchrotron beamline an...
متن کاملSynchrotron radiation applications to macromolecular crystallography.
Progress has been rapid in the development and application of four different types of macromolecular crystallographic experiment at synchrotron hard X-ray sources: multiwavelength anomalous diffraction; studies of crystals with very large unit cell dimensions; structure determination at atomic or near-atomic resolution; and time-resolved studies. The results illustrate the interplay between the...
متن کاملImpact of synchrotron radiation on macromolecular crystallography: a personal view
The introduction of synchrotron radiation sources almost four decades ago has led to a revolutionary change in the way that diffraction data from macromolecular crystals are being collected. Here a brief history of the development of methodologies that took advantage of the availability of synchrotron sources are presented, and some personal experiences with the utilization of synchrotrons in t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Crystallographica Section D Biological Crystallography
سال: 1999
ISSN: 0907-4449
DOI: 10.1107/s0907444999008288